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Skin Involvement in Amyotrophic Lateral Sclerosis lancet 347:1226-1227, Kolde,G.,et al, 1996 See this aricle in Pubmed Article Abstract Seven patients with sporadic ALS were investigated;five were confined to bed,but none had bedsores.Light and electron microscopy of skin showed an edematous dermis with collagen fibrils of irregular diameter.Small blood vessels were characterized by duplicated basement membranes and deposition of B-amyloid protein,the main component of the neuronal and non-neuronal amyloid deposits in Alzheimer's disease.These skin changes were seen in all degrees of disability but none was found in age-matched and sex- matched controls.The skin in ALS is characterized by a distinctive pattern of alterations of connective tissue and blood vessels.Examination of skin is an additional and easily accessible investigation which may help elucidate the pathogenesis of ALS.

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(click to filter results - removes previous filter) amyotrophic lateral sclerosis pressure sores skin,biopsy skin,lesions in neurologic disorders vasculopathy

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